University of Copenhagen researchers developed a once-a-day treatment that could replace traditional creams and ointments, for millions of individuals living with psoriasis, a chronic autoimmune condition characterized by inflamed, scaly skin, the journey toward effective relief has been filled with challenges. Traditional treatments like topical creams, phototherapy, and systemic medications often provide only partial relief or come with undesirable side effects.
However, a groundbreaking innovation is reshaping the landscape of psoriasis care: a revolutionary patch designed to offer targeted treatment with remarkable efficacy. This cutting-edge approach minimizes side effects and promises a more convenient and comfortable solution for patients, heralding a new era in psoriasis management.
A Common Skin Condition Meets a Promising Innovation
Psoriasis, a chronic inflammatory skin disease affecting 4–5% of the Danish population, has long posed challenges for patients and healthcare providers. The condition, characterized by red, scaly rashes that vary in severity, requires consistent treatment to manage symptoms. While creams and ointments are widely used, their effectiveness is often hampered by the inconvenience of frequent application and the greasy residue they leave behind.
Researchers at the University of Copenhagen have developed a novel solution: a dry patch that delivers active ingredients directly to the skin, requiring just one daily application. The innovation could significantly improve treatment adherence and comfort for patients.
How the Patch Works: A Dual-Action Approach
The prototype patch is designed to release two active ingredients in a controlled, time-sensitive manner. Salicylic acid is deployed immediately to remove dead skin cells, while hydrocortisone, an anti-inflammatory agent, is released gradually to reduce skin inflammation. This dual-action approach mimics the effectiveness of standard creams while offering a far more convenient and user-friendly alternative.
Anna-Lena Gürtler, the lead author on several studies exploring the patch, explained: “We’ve tested the prototype on pig skin and human skin cells and compared it to creams available at pharmacies. Our studies show that the patch is as effective as traditional treatments.”
Electrospinning makes The patch’s design possible, where high voltage is applied to a polymer solution to produce synthetic nanofibers. These fibers form a mat-like structure that adheres to the skin, functioning like a plaster while delivering medication.
Beyond Psoriasis: Potential Applications for Other Skin Conditions
While the patch is still developing and requires additional research and clinical trials, its potential extends beyond psoriasis treatment. Associate Professor Andrea Heinz, the project’s lead researcher, noted, “A patch containing active ingredients may be an alternative to creams and ointments for other inflammatory skin diseases, such as atopic eczema. It may also have applications in wound healing.”
This innovation represents a promising leap forward for patients who struggle with the daily burden of managing skin conditions. Though it may take time before the patch reaches pharmacies, the concept demonstrates how scientific advancements can make everyday treatments more effective and accessible.
Reference: Anna-Lena Gürtler, Jonathan P. Sirois, Julia C. Lang, Keira Melican, Thomas Rades, Andrea Heinz. Electrospun dressings with a dual release functionality of two anti-inflammatory active ingredients. RSC Pharmaceutics, 2024
